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1-chloro-3-(1H-indole-4-oxy)propane

7-methyl-3-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indole

K2CO3

→

title compound

3-[4-(7-methyl-3-indolyl)-1,2,3,6-tetrahydropyridin-1-yl]-1-(4-indolyloxy)propane

용매

dimethylformamide

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실험 절차

The title compound was prepared in a fashion similar to that described in Example 99 using 1-chloro-3-(1H-indole-4-oxy)propane (0.499 g, 2.4 mmol) and 7-methyl-3-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indole (0.509 g, 2.4 mmol) in the presence of 2.0 equivalents of K2CO3 (0.593, 4.3 mmol) in dimethylformamide at 90° C. Yield 0.383 g (41%) of a tan powder. mp 166°-169° C. FDMS m/e=405 (M+ of free base).

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