반응 #56881

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4-(5-bromo-2-methyl-phenyl)-6-chloro-pyrimidin-2-ylamine

4-oxazol-4-yl-phenylamine

→

title compound

수율 61.0%

6-(5-Bromo-2-methyl-phenyl)-N*4*-(4-oxazol-4-yl-phenyl)-pyrimidine-2,4-diamine

수율 61.0%

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실험 절차

Following the method described in Example 26, 4-(5-bromo-2-methyl-phenyl)-6-chloro-pyrimidin-2-ylamine and 4-oxazol-4-yl-phenylamine provided the title compound (61% yield). 1H NMR (CD3OD) δ 2.41 (s, 3H, CH3), 6.37 (s, 1H, Ar), 7.38 (d, 1H, J=7.8 Hz, Ar), 7.61 (s, 1H, Ar), 7.66-7.69 (m, 2H, Ar), 7.81 (d, 2H, J=8.7 Hz, Ar), 7.99 (d, 2H, J=8.5 Hz, Ar), 8.43 (br s, 1H, NH).

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