반응 #56860

반응 방정식

4-nitro-benzaldehyde

tosylmethyl isocyanide

potassium carbonate

→

5-(4-nitro-phenyl)-oxazole

수율 89.0%

용매

methanol

반응 조건

후처리

1. 1
   온도was heated
2. 2
   온도under reflux for 30 minutes
3. 3
   농축After concentrating under reduced pressure
4. 4
   여과The solid that was filtered

실험 절차

A mixture of 4-nitro-benzaldehyde (5.0 g, 33.1 mmol), tosylmethyl isocyanide (6.4 g, 33.1 mmol) and potassium carbonate (7.8 g, 82.7 mmol) in methanol (100 ml) was heated under reflux for 30 minutes. After concentrating under reduced pressure, the residue was stirred with water (50 ml). The solid that was filtered to afford 5-(4-nitro-phenyl)-oxazole (5.6 g, 89% yield). 1H NMR (acetone-d6) δ 7.89 (s, 1H, Ar), 8.05 (d, 2H, J=9.3 Hz, Ar), 8.35-8.38 (m, 3H, Ar).

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