반응 #56852

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4-chloro-6-(5-chloro-2-ethoxy-phenyl)-pyrimidin-2-ylamine

4-amino-benzonitrile

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title compound

수율 74.0%

4-[2-Amino-6-(5-chloro-2-ethoxy-phenyl)-pyrimidin4-ylamino]-benzonitrile

수율 74.0%

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실험 절차

Following the method described in Example 53, 4-chloro-6-(5-chloro-2-ethoxy-phenyl)-pyrimidin-2-ylamine and 4-amino-benzonitrile provided the title compound (74% yield). 1H NMR (DMSO-d6) δ 1.41 (t, 3H, J=6.9 Hz, CH3), 4.15 (q, 2H, J=7.0 Hz, CH2), 6.53 (s, 2H, NH2), 6.84 (s, 1H, Ar), 7.17 (d, 1H, J-8.9 Hz, Ar), 7.43 (dd, 1H, J=8.8, 2.9 Hz, Ar), 7.71 (d, 2H, J=8.9 Hz, Ar), 7.92 (d, 1H, J=2.9 Hz, Ar), 8.00 (d, 2H, J=8.9 Hz, Ar), 9.70 (s, 1H, NH).

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