반응 #56823

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4-chloro-6-(5-chloro-2-methyl-phenyl)-pyrimidin-2-yl-amine

4-amino-benzonitrile

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title compound

수율 71.0%

4-[2-Amino-6-(5-chloro-2-methyl-phenyl)-pyrimidin4-ylamino]-benzonitrile

수율 71.0%

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실험 절차

Following the method described in Example 26, 4-chloro-6-(5-chloro-2-methyl-phenyl)-pyrimidin-2-yl-amine and 4-amino-benzonitrile provided the title compound (71% yield). 1H NMR (DMSO-d6) δ 2.36 (s, 3H, CH3), 6.19 (s, 1H, Ar), 6.61 (s, 2H, NH2), 7.32 (d, 1H, J=8.2 Hz, Ar), 7.38 (dd, 1H, J=8.2 Hz, J=2.3 Hz, Ar), 7.43 (d, 1H, J-2.3 Hz, Ar), 7.72 (d, 2H, J=8.8 Hz, Ar), 8.00 (d, 2H, J=8.8 Hz, Ar), 9.73 (s, 1H, NH).

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