반응 #567740

반응 방정식

isobutyl (R)-lactate

3,4-dihydro-2H-pyran

hydrogen chloride

→

isobutyl 2-O-tetrahydropyranyl-(R)-lactate

수율 89.0%

용매

calcium chloride

dimethylformamide

반응 조건

후처리

1. 1
   여과filtered
2. 2
   기타The product was isolated by distillation (13 Pa, b.p. 94∝96° C.)

실험 절차

A mixture of isobutyl (R)-lactate (73 g, 0.5 mol, Merck) and 3,4-dihydro-2H-pyran (70 g, 0.83 mol, Merck) was treated with 5M hydrogen chloride in dimethylformamide (4 ml) and set aside at ambient temperature overnight in calcium chloride protected 250 ml round-bottom flask. Silver oxide (15 g) was added, the mixture stirred magnetically for 2 hours and then filtered. The product was isolated by distillation (13 Pa, b.p. 94∝96° C.) to provide isobutyl 2-O-tetrahydropyranyl-(R)-lactate (102.5 g, 89%) as a colorless oil.

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