반응 #567514

반응 방정식

3-(2-amino-ethyl)-benzoic acid methyl ester

benzoic acid methyl ester

methanesulfonyl chloride

triethylamine

→

title compound

수율 79.6%

3-(2-Methanesulfonylamino-ethyl)-benzoic acid methyl ester

수율 79.6%

용매

CH2Cl2

CH2Cl2

반응 조건

후처리

1. 1
   세척was washed consecutively with 5.5% HCl, water, saturated NaHCO3, and brine
2. 2
   건조The organic solution was dried over MgSO4
3. 3
   여과filtered
4. 4
   농축concentrated

실험 절차

To a solution of 3-(2-amino-ethyl)-benzoic acid methyl ester (500 mg) in CH2Cl2 (35 mL) at 0° C. was added amino-ethyl)-benzoic acid methyl ester (500 mg) in CH2Cl2 (35 mL) at 0° C. was added methanesulfonyl chloride (292 mg, 2.55 mmol) and triethylamine (1.6 mL, 11.5 mmol). The reaction was stirred at room temperature for 18 h and was washed consecutively with 5.5% HCl, water, saturated NaHCO3, and brine. The organic solution was dried over MgSO4, filtered, and concentrated to yield the title compound (522 mg) as a white solid. MS 275 (M+18).

출처