반응 #56668
ord-f153600557c0416791bf202cd4833cdf
반응 방정식
반응 조건
상세 조건
See reaction.notes.procedure_details.
후처리
- 1추출extracted with ethyl acetate
- 2기타dried
- 3기타the solvent is evaporated off
- 4기타The residue is purified by chromatography on a silica gel column
- 5세척eluting with an 8/2 cyclohexane/ethyl acetate mixture
- 6기타The compound of the title is obtained
실험 절차
A mixture of 2.0 g (0.0008 mol) of trans-ethyl 4-(4-aminocyclohexyl)benzoate, 1.25 ml of triethylamine and 1.26 ml (0.0084 mol) of benzyl chloroformate at 95% in 40 ml of dimethylformamide is stirred at room temperature for 3 hours. The mixture is poured into water, extracted with ethyl acetate and dried, and the solvent is evaporated off. The residue is purified by chromatography on a silica gel column, eluting with an 8/2 cyclohexane/ethyl acetate mixture. The compound of the title is obtained.