반응 #566645

반응 방정식

1-(2methoxycarbonylethyl)-3-(1-benzylpiperidin-4-yl)-4-phenyl-3,4-dihydro-2(1H)-quinazolinone

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title compound

1-(2-Carboxyethyl)-3-(1-benzylpiperidin-4-yl)-4-phenyl-3,4-dihydro-2(1H)-quinazolinone

용매

methanol

sodium hydroxide

반응 조건

후처리

1. 1
   농축After neutralization with 1N hydrochloric acid, the reaction mixture was concentrated under reduced pressure
2. 2
   추출extracted with ethyl acetate
3. 3
   건조dried over anhydrous sodium sulfate
4. 4
   기타The solvent was evaporated under reduced pressure
5. 5
   workup.ADDITIONEther was added to the residue
6. 6
   기타precipitated crystals
7. 7
   기타were collected

실험 절차

To a solution of 78 mg (0.16 mmol) of 1-(2methoxycarbonylethyl)-3-(1-benzylpiperidin-4-yl)-4-phenyl-3,4-dihydro-2(1H)-quinazolinone in 1 ml of methanol, 0.5 ml of 1N aqueous sodium hydroxide solution was added and stirred at room temperature for 2.5 hours. After neutralization with 1N hydrochloric acid, the reaction mixture was concentrated under reduced pressure, extracted with ethyl acetate and dried over anhydrous sodium sulfate. The solvent was evaporated under reduced pressure. Ether was added to the residue and precipitated crystals were collected to give the title compound as colorless powder.

출처