반응 #56591
ord-a770b83f1db64c9a9292a5aa6bd5ee65
반응 방정식
sodium bicarbonate
ether
dihydropyrane
6-chlorohexanol
→
product
수율 86.6%
2-(6-Chlorohexyloxy)tetrahydropyrane
수율 86.6%
반응 조건
상세 조건
See reaction.notes.procedure_details.
후처리
- 1세척The ether phase was washed with water
- 2건조dried over sodium sulphate
- 3여과filtered
- 4농축concentrated to dryness
실험 절차
To a mixture of 15 g of 6-chlorohexanol, 100 ml of methylenechloride and 0.2 g of p-toluenesulphonic acid were added dropwise 12 g of dihydropyrane in 40 ml of methylenechloride. The reaction mixture was stirred for 15 h at room temperature and then distributed between ether and saturated sodium bicarbonate solution. The ether phase was washed with water, dried over sodium sulphate, filtered and concentrated to dryness. Chromatography of the residue on silica using hexane/ether (3:1) gave 21 g of the product as a colourless oil.