반응 #56590

반응 방정식

2-(6-chlorohexyloxy)tetrahydropyrane

hydroquinone

potassiumcarbonate

potassiumiodide

→

product

수율 82.5%

4-(6-(2-Tetrahydropyranyl)oxyhexyloxy)phenol

수율 82.5%

용매

dimethylsulfoxide

water

반응 조건

후처리

1. 1
   기타to react for 4 days at 80° C
2. 2
   추출extracted with ether
3. 3
   건조The organic phase was then dried over sodium sulphate
4. 4
   여과filtered
5. 5
   농축concentrated to dryness

실험 절차

A mixture of 10 g of 2-(6-chlorohexyloxy)tetrahydropyrane, 25 g of hydroquinone, 31 g of potassiumcarbonate, 0.752 g of potassiumiodide and 250 ml of dimethylsulfoxide was allowed to react for 4 days at 80° C. Subsequently, the reaction mixture was cooled to room temperature and after addition of water extracted with ether. The organic phase was then dried over sodium sulphate, filtered and concentrated to dryness. Chromatography on silica with 10% ethylacetate in toluene gave 11 g of product as a yellowish oil.

출처