반응 #56578

반응 방정식

z,z,z-octadeca-6,9,12-trienoic acid

1,3-dihydroxypropane

1,3-dicyclohexylcarbodiimide

→

1-(z,z,z-octadeca-6,9,12-trienoyloxy)-3-hydroxypropane

용매

methylene chloride

methylene chloride

반응 조건

후처리

1. 1
   여과was filtered
2. 2
   세척The filtrate was washed with dilute hydrochloric acid, water and saturated sodium chloride solution
3. 3
   기타The solution was dried
4. 4
   농축concentrated
5. 5
   기타purified
6. 6
   기타by dry column chromatography

실험 절차

A solution of z,z,z-octadeca-6,9,12-trienoic acid (150 g) in methylene chloride (500 ml) was added dropwise to a mixture of 1,3-dihydroxypropane (205 g), 1,3-dicyclohexylcarbodiimide (130 g) and 4-(N,N-dimethylamino)pyridine (87 g) in methylene chloride (2500 ml) at room temperature under nitrogen. When tlc indicated that the reaction had gone to completion the reaction mixture was filtered. The filtrate was washed with dilute hydrochloric acid, water and saturated sodium chloride solution. The solution was dried, concentrated and purified by dry column chromatography to yield 1-(z,z,z-octadeca-6,9,12-trienoyloxy)-3-hydroxypropane as a pale yellow oil.

출처