반응 #56537

반응 방정식

2-cyano-2-(2,4-dichlorophenyl)decan-1-ol

methane sulfonyl chloride

triethylamine

→

2-cyano-2-(2,4-dichlorophenyl)decyl methane sulfonate

용매

benzene

반응 조건

후처리

1. 1
   workup.ADDITIONis added dropwise at 10° C.
2. 2
   온도heated on a steam bath for another 30 minutes
3. 3
   기타The precipitate formed
4. 4
   여과is filtered
5. 5
   세척the filtrate is washed with dilute hydrochloric acid, water, saturated sodium bicarbonate solution, saturated sodium chloride solution
6. 6
   건조dried over magnesium sulfate
7. 7
   기타The solvent is evaporated
8. 8
   기타to give 41.3 g

실험 절차

To a mixture of 2-cyano-2-(2,4-dichlorophenyl)decan-1-ol (40 g., 0.12 mole) and methane sulfonyl chloride (15.3 g., 0.13 mole) in 2 liters of benzene is added dropwise at 10° C., 14.8 g., (0.14 mole) of triethylamine. The reaction mixture is stirred at room temperature for 30 minutes and then heated on a steam bath for another 30 minutes. The precipitate formed is filtered and the filtrate is washed with dilute hydrochloric acid, water, saturated sodium bicarbonate solution, saturated sodium chloride solution and dried over magnesium sulfate. The solvent is evaporated to give 41.3 g. of product, which is identified by nmr.

출처