반응 #56536

반응 방정식

α-n-octyl-2,4-dichlorobenzyl cyanide

pyridine

paraformaldehyde

benzyl triethylammonium hydroxide

→

2-cyano-2-(2,4-dichlorophenyl)decan-1-ol

용매

water

반응 조건

후처리

1. 1
   workup.ADDITIONis added 1 ml
2. 2
   추출extracted with ether
3. 3
   세척The combined ether extracts are washed with water, saturated sodium chloride solution
4. 4
   건조dried over magnesium sulfate
5. 5
   기타The solvent is evaporated
6. 6
   기타to give 40 g

실험 절차

To an ice cold stirred solution of α-n-octyl-2,4-dichlorobenzyl cyanide (40 g., 0.14 mole) in 250 ml. of pyridine containing a suspension of paraformaldehyde (21 g., 0.7 mole) is added 1 ml. of benzyl triethylammonium hydroxide. The mixture is stirred under nitrogen at room temperature for 72 hours. The reaction mixture is poured into 2 liters of water and extracted with ether. The combined ether extracts are washed with water, saturated sodium chloride solution and dried over magnesium sulfate. The solvent is evaporated to give 40 g. of a thick oil.

출처