반응 #56534

반응 방정식

2-cyano-2-(2,4-dichlorophenyl)hexyl methane sulfonate

imidazole

N,N-dimethylformamide

→

expected product

수율 68.0%

1-[2-cyano-2-(2,4-dichlorophenyl)hexyl]imidazole hydrochloride

수율 68.0%

용매

water

반응 조건

후처리

1. 1
   온도is heated
2. 2
   추출extracted with ether
3. 3
   건조The combined ether extracts are dried over magnesium sulfate
4. 4
   여과The drying agent is filtered and into the ethereal solution
5. 5
   기타is bubbled dry hydrogen chloride gas
6. 6
   기타The white solid which precipitates
7. 7
   기타is collected
8. 8
   기타dried
9. 9
   기타to give 70.4 g

실험 절차

A mixture of 2-cyano-2-(2,4-dichlorophenyl)hexyl methane sulfonate (100 g., 0.29 mole), imidazole (100 g., 1.5 mole) and N,N-dimethylformamide (5 ml.) is heated with stirring at 135° C. overnight. The reaction mixture is poured into water and extracted with ether. The combined ether extracts are dried over magnesium sulfate. The drying agent is filtered and into the ethereal solution is bubbled dry hydrogen chloride gas. The white solid which precipitates is collected and dried to give 70.4 g. (68%) of the expected product, which is identified by nmr.

출처