반응 #56532

반응 방정식

a-n-butyl-2,4-dichlorobenzyl cyanide

pyridine

paraformaldehyde

→

2-cyano-2-(2.4-dichlorophenyl)hexan-1-ol

용매

benzene triethylammonium hydroxide

반응 조건

후처리

1. 1
   workup.ADDITIONis added 1 ml
2. 2
   workup.ADDITIONThe reaction mixture is poured into 300 ml
3. 3
   추출of water and extracted with ether
4. 4
   세척The combined ether extracts are washed with water, saturated sodium chloride solution
5. 5
   건조dried over magnesium sulfate
6. 6
   기타The solvent is evaporated
7. 7
   기타to give 5.6g

실험 절차

To an ice cold stirred solution of a-n-butyl-2,4-dichlorobenzyl cyanide (5g., 0.02 mole) in 20 ml. of pyridine containing a suspension of paraformaldehyde (2.4g., 0.08 mole) is added 1 ml. of benzene triethylammonium hydroxide. The mixture is stirred under nitrogen at room temperature for 16 hours. The reaction mixture is poured into 300 ml. of water and extracted with ether. The combined ether extracts are washed with water, saturated sodium chloride solution and dried over magnesium sulfate. The solvent is evaporated to give 5.6g. of a thick oil, which is identified by nmr.

출처