반응 #565308

반응 방정식

HCl

Methyl 3,5-dichloro-4-hydroxybenzoate

1-bromododecane

potassium carbonate

potassium carbonate

→

Methyl 3,5-Dichloro-4-dodecyloxybenzoate

용매

DMF

반응 조건

후처리

1. 1
   온도The reaction was cooled
2. 2
   추출The mixture was then extracted with ethyl acetate
3. 3
   세척The ethyl acetate was washed with 2N-HCl(×3)
4. 4
   건조dried (MgSO4)
5. 5
   여과filtered
6. 6
   농축concentrated
7. 7
   기타to give an oil
8. 8
   기타This oil was taken on to the next step without further purification

실험 절차

Methyl 3,5-dichloro-4-hydroxybenzoate, (173, 0.78 mol), 1-bromododecane (234 g, 0.94 mol) and potassium carbonate (130 g, 0.94 g) in DMF (1000 mL) were heated to 70° C. with good stirring for about 8 hrs. The reaction was cooled and treated with 2N-HCl to neutralize the excess potassium carbonate. The mixture was then extracted with ethyl acetate. The ethyl acetate was washed with 2N-HCl(×3), dried (MgSO4), filtered and concentrated to give an oil. This oil was taken on to the next step without further purification.

출처