반응 #56527

반응 방정식

2-chloro-5-nitro-benzotrifluoride

sodium hydroxide

methanol

water

→

2-methoxy-5-nitro-benzotrifluoride

수율 60.7%

반응 조건

후처리

1. 1
   추출extracted with methylene chloride
2. 2
   기타After evaporating off the solvent
3. 3
   기타the compound is recrystallised from isopropanol

실험 절차

45 g of sodium hydroxide and 10 g of tetraethylammonium chloride in 200 g of methanol are initially introduced, 112.5 g of 2-chloro-5-nitro-benzotrifluoride are added dropwise at 25° to 30° C. and the mixture is then stirred at 30° C. for a further 5 hours. The mixture is then poured into 250 ml of water and extracted with methylene chloride. After evaporating off the solvent, the compound is recrystallised from isopropanol. 67 g of 2-methoxy-5-nitro-benzotrifluoride with a melting point of 70° to 74° C. are obtained.

출처