반응 #5648

반응 방정식

tribromide

1,3,5-trisbromomethyl benzene

nitronium tetrafluoroborate

water

→

nitro

수율 86.4%

2,4,6-Tris(bromomethyl)nitrobenzene

수율 86.4%

용매

CH3CN

CH3CN

반응 조건

후처리

1. 1
   추출the mixture extracted with CH2Cl2
2. 2
   세척The CH2Cl2 extracts were washed with 10% NaHCO3
3. 3
   건조dried (Na2SO4) and solvents
4. 4
   기타removed

실험 절차

To a solution of 5 g (0.014 mole) of the tribromide 8 in 100 ml of CH3CN was added, at room temperature and under argon atmosphere, in a dropwise fashion 3.72 g (0.028 mole) of nitronium tetrafluoroborate in 200 ml of CH3CN. The solution was then stirred for 20 minutes longer, poured into water and the mixture extracted with CH2Cl2. The CH2Cl2 extracts were washed with 10% NaHCO3, dried (Na2SO4) and solvents removed to afford 4.86 g (86%) of the desired nitro compound 27: NMR (CDCl3) 4.5 (s,6,--CH2Br), 7.55 (s,--C6H2).

출처