반응 #5647

반응 방정식

diester

4-(2-methoxy-4-benzyloxyphenyl)pyridine-2,6-dicarboxylic acid dimethyl ester

→

phenol

수율 89.0%

4-(2-methoxy-4-hydroxyphenyl)pyridine 2,6-dicarboxylic acid dimethyl ester

수율 89.0%

용매

ethanol

반응 조건

후처리

1. 1
   기타The container for the resulting suspension was evacuated
2. 2
   workup.ADDITIONfilled with H2 (repeated three times)
3. 3
   workup.ADDITIONfilled rubber bladder for 60 hours with very rapid stirring
4. 4
   여과The mixture was then filtered
5. 5
   기타to remove catalyst
6. 6
   기타the solvent was removed from the filtrate by rotary evaporation
7. 7
   기타The resulting oil was dried in vacuo

실험 절차

To a solution of 7 g (0.174 mole) of the diester 23 in 200 ml of ethanol was added 1.0 g of 10% Pd/C. The container for the resulting suspension was evacuated and filled with H2 (repeated three times) and kept under a positive atomosphere by means of a hydrogen-filled rubber bladder for 60 hours with very rapid stirring. The mixture was then filtered to remove catalyst and the solvent was removed from the filtrate by rotary evaporation. The resulting oil was dried in vacuo yielding after several hours (4.9 g) 89% of the desired phenol 24 as a solid.

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