반응 #56421

반응 방정식

potassium iodide

1-iodopropane

N-(2,6-dimethylphenyl)-4-piperidinamine

sodium carbonate

→

N-(2,6-dimethylphenyl)-1-propyl-4-piperidinamine

용매

benzene

benzene

water

반응 조건

후처리

1. 1
   workup.ADDITIONAfter the addition
2. 2
   workup.STIRRINGstirring
3. 3
   온도at reflux temperature
4. 4
   온도The reaction mixture is cooled
5. 5
   기타The organic layer is separated
6. 6
   기타dried
7. 7
   기타evaporated in vacuo
8. 8
   workup.DISTILLATIONThe oily residue is distilled

실험 절차

To a warm (about 40° C.) and stirred mixture of 5 parts of N-(2,6-dimethylphenyl)-4-piperidinamine, 5 parts of sodium carbonate, a few crystals of potassium iodide in 120 parts of benzene is added dropwise a solution of 5.1 parts of 1-iodopropane in 80 parts of benzene. After the addition is complete, stirring is continued for 40 hours at reflux temperature. The reaction mixture is cooled and 50 parts of water are added. The organic layer is separated, dried and evaporated in vacuo. The oily residue is distilled, yielding 10.2 parts of N-(2,6-dimethylphenyl)-1-propyl-4-piperidinamine; bp. 135° C. at 0.2 mm. pressure.

출처