반응 #564153

반응 방정식

methyl β-aminocrotonate

methyl (2,2-difluoro-1,3-benzodioxol-5-yl)-methylene-acetoacetate

→

Dimethyl 4-(2,2-difluoro-1,3-benzodioxol-5-yl)-1,4-dihydro-2,6-dimethyl-pyridine-3,5-dicarboxylate

용매

methanol

반응 조건

후처리

1. 1
   기타the methanol is evaporated off
2. 2
   기타the residue is chromatographed on silica gel with chloroform

실험 절차

20 mmol of methyl β-aminocrotonate and 20 mmol of crude methyl (2,2-difluoro-1,3-benzodioxol-5-yl)-methylene-acetoacetate are heated under reflux in 30 ml of methanol for 12 hours, the methanol is evaporated off and the residue is chromatographed on silica gel with chloroform. The evaporated product fraction is taken up in a little methylene chloride and the mixture is foamed to a glass by rapid evacuation.

출처