반응 #564082

반응 방정식

thionyl chloride

2-[4-(2,4-difluorophenyl)piperazin-1-yl]ethanol

→

1-chloro-2-[4-(2,4-difluorophenyl)piperazin-1-yl]ethane hydrochloride

용매

chloroform

반응 조건

후처리

1. 1
   workup.ADDITIONWhen the addition
2. 2
   온도the reaction mixture is heated
3. 3
   온도under reflux for 5 hours
4. 4
   기타After return to room temperature, the crystals formed
5. 5
   여과are filtered off
6. 6
   세척carefully washed with acetone
7. 7
   기타dried

실험 절차

40 ml of thionyl chloride are added dropwise to a solution of 60 g of 2-[4-(2,4-difluorophenyl)piperazin-1-yl]ethanol, prepared in Example 2, in 300 ml of chloroform. When the addition is complete, the reaction mixture is heated under reflux for 5 hours. After return to room temperature, the crystals formed are filtered off, carefully washed with acetone and then dried to give 70 g of 1-chloro-2-[4-(2,4-difluorophenyl)piperazin-1-yl]ethane hydrochloride in the form of crystals melting at 218° C.

출처