반응 #56388

반응 방정식

2-cyclopropylamino-4,6-dichloro-s-triazine

dioxane

ammonia

→

2-cyclopropylamino-4-chloro-6-amino-s-triazine

용매

ether

반응 조건

후처리

1. 1
   온도The reaction mixture is heated to 50° C.
2. 2
   농축concentrated by evaporation under water jet vaccum
3. 3
   workup.ADDITIONThe dry riesidue is diluted with 500 ml
4. 4
   workup.STIRRINGof water and after stirring for 1 hour at room temperature
5. 5
   기타the tiny white crystals formed
6. 6
   기타are separated
7. 7
   여과by filtering under suction
8. 8
   기타dried under water jet vacuum at 80° C

실험 절차

138 g of 2-cyclopropylamino-4,6-dichloro-s-triazine are added at a slightly elevated tmeperature and with vigorous stirring to a mixture of 675 ml of dioxane and 135 ml of ether. After cooling to room temperature, 101 ml of 25%, aqueous ammonia are added dropwise over a period of 20 minutes. The reaction mixture is heated to 50° C., stirred for 16 hours and then concentrated by evaporation under water jet vaccum. The dry riesidue is diluted with 500 ml. of water and after stirring for 1 hour at room temperature, the tiny white crystals formed are separated by filtering under suction and dried under water jet vacuum at 80° C. 217 g. of 2-cyclopropylamino-4-chloro-6-amino-s-triazine are obtained.

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