반응 #563874

반응 방정식

N-phenyl-1,2-ethanediamine

triethylamine

ethyl chloroformate

6-[2-(3,4-Dimethoxyphenyl)ethylamino]-6-oxohexanoic acid

→

title compound

수율 65.2%

N-[2-(3,4-Dimethoxyphenyl)ethyl]-N'-[2-(phenylamino) ethyl]hexanediamide

수율 65.2%

용매

dichloromethane

반응 조건

후처리

1. 1
   세척After washing with water
2. 2
   건조drying (Na2SO4)
3. 3
   기타the reaction mixture was evaporated
4. 4
   기타the residue recrystallised from ethyl acetate

실험 절차

6-[2-(3,4-Dimethoxyphenyl)ethylamino]-6-oxohexanoic acid (6.0 g, 0.19) was dissolved in dry dichloromethane (200 ml) and triethylamine (2.28 g, 0.021 mole), and ethyl chloroformate (1.86 ml, 0.019 mole) added at O°. After 1 hour at 0° N-phenyl-1,2-ethanediamine (2.64 g, 0.019 mole) was added and the mixture stirred at room temperature for 18 hr. After washing with water and drying (Na2SO4), the reaction mixture was evaporated and the residue recrystallised from ethyl acetate to give the sub title compound (5.3 g) mp 109°-11°.

출처