반응 #56387

반응 방정식

cyanuric chloride

cyclopropylamine

sodium hydroxide

→

2-cyclopropylamino-4,6-dichloro-s-triazine

용매

chlorobenzene

반응 조건

후처리

1. 1
   workup.ADDITIONTo this suspension are added
2. 2
   기타at -10° C.
3. 3
   workup.WAITto stand for a further 16 hours at room temperature
4. 4
   세척after which it is washed with water (2×400 ml)
5. 5
   건조dried over anhydrous sodium sulphate
6. 6
   여과filtered
7. 7
   기타The excess chlorobenzene is then removed by water jet vacuum distillation

실험 절차

133 g of cyanuric chloride are suspended in 720 ml of chlorobenzene and cooled to -10° C. To this suspension are added with stirring 50 ml of cyclopropylamine dropwise over a period of 25 minutes. Keeping the temperature at -10° C., 96 ml of aqueous sodium hydroxide (30% NaOH) are added dropwise. The reaction mixture is then stirred at -10° C. for 11/2 hours and allowed to stand for a further 16 hours at room temperature, after which it is washed with water (2×400 ml), dried over anhydrous sodium sulphate and filtered. The excess chlorobenzene is then removed by water jet vacuum distillation. 138 g of 2-cyclopropylamino-4,6-dichloro-s-triazine in the form of white crystals are obtained.

출처