반응 #56312

반응 방정식

2-Methoxyaniline

sodium carbonate

2-Bromomethyl-4,5-dimethyl-1,3-dioxolane

→

N-(4,5-dimethyl-1,3-dioxolan-2-ylmethyl)-2-methoxyaniline

반응 조건

후처리

1. 1
   기타equipped with a mechanical stirrer
2. 2
   온도thermometer and reflux condenser
3. 3
   여과After this time the reaction mixture was filtered
4. 4
   workup.ADDITIONadditional sodium carbonate (5.00 grams) was added to the filtrate
5. 5
   workup.DISTILLATIONThe mixture was then distilled under reduced pressure

실험 절차

2-Methoxyaniline (87 ml; 0.7 mole) and sodium carbonate (31.66 grams) were charged into a glass reaction vessel equipped with a mechanical stirrer, thermometer and reflux condenser. 2-Bromomethyl-4,5-dimethyl-1,3-dioxolane (25 mls) was added and the reaction mixture was heated at a temperature of 100° C. for a period of about 4 hours. After this time the reaction mixture was filtered and additional sodium carbonate (5.00 grams) was added to the filtrate. The mixture was then distilled under reduced pressure to yield the desired product N-(4,5-dimethyl-1,3-dioxolan-2-ylmethyl)-2-methoxyaniline boiling at 125° to 128° C. at 0.1 mm of Hg pressure.

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