반응 #56307

반응 방정식

phosphate

1-(2-tetrahydropyranyl)-3-phenylacetamido-4-[2-(2-tetrahydropyranyl)oxyethyl]-2-azetidinone

p-toluenesulfonic acid monohydrate

→

3-phenylacetamido-4-(2-hydroxyethyl)-2-azetidinone

용매

methanol

반응 조건

후처리

1. 1
   추출The product is extracted into ethyl acetate
2. 2
   세척The ethyl acetate solution is washed with brine
3. 3
   건조dried over magnesium sulfate
4. 4
   여과filtered
5. 5
   기타The filtrate is evaporated under reduced pressure

실험 절차

A solution of 1-(2-tetrahydropyranyl)-3-phenylacetamido-4-[2-(2-tetrahydropyranyl)oxyethyl]-2-azetidinone in methanol at 25° C. is treated with 0.1 molar equivalent of p-toluenesulfonic acid monohydrate. The solution is stirred for a period of 2 hours and then neutralized with 1 M pH 7 phosphate buffer. The product is extracted into ethyl acetate. The ethyl acetate solution is washed with brine, dried over magnesium sulfate and filtered. The filtrate is evaporated under reduced pressure to give 3-phenylacetamido-4-(2-hydroxyethyl)-2-azetidinone.

출처