반응 #56299

반응 방정식

7β-(t-Butoxycarbonyl)amino-3-[2-(N-carboethoxycarbamoyl)benzoyloxy]methyl-3-cephem-4-carboxylic acid

→

7β-amino-3-[2-(N-carboethoxycarbamoyl)benzoyloxy]methyl-3-cephem-4-carboxylic acid

수율 86.7%

용매

trifluoroacetic acid

반응 조건

후처리

1. 1
   온도cooling
2. 2
   농축The solution is concentrated and to the residue, ether (20 ml)
3. 3
   workup.ADDITIONis added
4. 4
   기타The resultant precipitate is triturated
5. 5
   여과collected by filtration
6. 6
   세척washed with ether
7. 7
   건조dried over phosphorus pentoxide

실험 절차

7β-(t-Butoxycarbonyl)amino-3-[2-(N-carboethoxycarbamoyl)benzoyloxy]methyl-3-cephem-4-carboxylic acid (275 mg) is dissolved in trifluoroacetic acid (2 ml) under ice-cooling and the mixture is stirred for 20 minutes. The solution is concentrated and to the residue, ether (20 ml) is added. The resultant precipitate is triturated, collected by filtration, washed with ether and dried over phosphorus pentoxide. The procedure provides 7β-amino-3-[2-(N-carboethoxycarbamoyl)benzoyloxy]methyl-3-cephem-4-carboxylic acid (195 mg). In NMR spectrum, this product is good agreement with the product obtained in Example 20.

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