반응 #562750

반응 방정식

2-hydroxyindane

diisopropyl azodicarboxylate

tri(n-butyl)phosphine

2-hydroxyindane

diisopropyl azodicarboxylate

tri(n-butyl)phosphine

N-[2-(3-hydroxy-4-methoxy phenyl)oxazol-4-ylmethyl]-3-methylpicolinamide

N-[2-(3-hydroxy-4-methoxyphenyl)oxazol-4-ylmethyl]-3-methylpicolinamide

→

N-{2-[3-(indan-2-yloxy)-4-methoxyphenyl]oxazol-4-ylmethyl}-3-methylpicolinamide

용매

tetrahydrofuran

반응 조건

후처리

1. 1
   workup.WAITat 50° C. for 2.5 hours
2. 2
   workup.STIRRINGthe mixture was stirred at 50° C. for 5 hours
3. 3
   기타at room temperature
4. 4
   기타overnight
5. 5
   농축The reaction mixture was concentrated under reduced pressure
6. 6
   기타The residue was purified by silica gel column chromatography (n-hexane:ethyl acetate:methylene chloride=1:1:1)

실험 절차

A 170 mg quantity of the N-[2-(3-hydroxy-4-methoxy phenyl)oxazol-4-ylmethyl]-3-methylpicolinamide obtained in Example 17 was dissolved in 10 ml of tetrahydrofuran. To the obtained solution were added 134 mg of 2-hydroxyindane, 0.5 ml of diisopropyl azodicarboxylate (40% toluene solution) and 202 mg of tri(n-butyl)phosphine, and the mixture was stirred at room temperature overnight, and at 50° C. for 2.5 hours. To the reaction mixture were added 100 mg of 2-hydroxyindane, 0.5 ml of diisopropyl azodicarboxylate (40% toluene solution) and 200 mg of tri(n-butyl)phosphine, and the mixture was stirred at 50° C. for 5 hours, and at room temperature overnight. The reaction mixture was concentrated under reduced pressure. The residue was purified by silica gel column chromatography (n-hexane:ethyl acetate:methylene chloride=1:1:1) to give 92 mg of N-{2-[3-(indan-2-yloxy)-4-methoxyphenyl]oxazol-4-ylmethyl}-3-methylpicolinamide.

출처