반응 #56259

반응 방정식

adenosine-5'-carboxylic acid methyl ester

hydrazine hydrate

→

adenosine-5'-carboxylic acid hydrazide

수율 93.0%

용매

methanol

반응 조건

후처리

1. 1
   온도heated to the boil
2. 2
   기타while, almost simultaneously, the hydrazide precipitates out in the form of a fine crystalline material
3. 3
   여과it is filtered off with suction
4. 4
   세척washed with methanol
5. 5
   기타dried

실험 절차

5 g of adenosine-5'-carboxylic acid methyl ester are suspended in 150 ml of methanol mixed with 20 ml of hydrazine hydrate and heated to the boil. The ester thereby goes into solution, while, almost simultaneously, the hydrazide precipitates out in the form of a fine crystalline material. After standing overnight, it is filtered off with suction, washed with methanol and dried. There are obtained 4.4 g of adenosine-5'-carboxylic acid hydrazide, which melts, with decomposition, at 270°-272° C. The yield is 93% of theory. The compound can be readily recrystallized from hot water.

출처