반응 #56257

반응 방정식

adenosine-5'-carboxylic acid methyl ester

triethylamine

→

Adenosine-5'-carboxylic acid benzyl ester

용매

benzyl alcohol

반응 조건

후처리

1. 1
   기타After termination of the reaction
2. 2
   기타the residue is triturated with ether for the removal of traces of amine and solvent
3. 3
   여과after filtering off with suction
4. 4
   기타the product is recrystallized from water

실험 절차

5 g of adenosine-5'-carboxylic acid methyl ester are suspended in 200 ml of benzyl alcohol, with the addition of 7 g of triethylamine, and the reaction mixture heated to 100° C. for 5 hours, the methyl ester thereby going into solution. After termination of the reaction, the base and excess alcohol are stripped off in a vacuum, the residue is triturated with ether for the removal of traces of amine and solvent and, after filtering off with suction, the product is recrystallized from water. There are thus obtained 3.3 g (53% of theory) of adenosine-5'-carboxylic acid benzyl ester, which has a melting point of 144°-145° C.

출처