반응 #56223

반응 방정식

3-benzylpyrrolylmethyl methanesulfonate

2-(6-Chloro-2-benzothienyl)-3-methylbutanoic acid

→

3-benzylpyrrolylmethyl 2-(6-chloro-2-benzothienyl)-3-methylbutanoate

용매

THF DMF

THF DMF

ether

반응 조건

후처리

1. 1
   세척washed with water (3×) and sat. NaCl
2. 2
   기타dried
3. 3
   기타solvent is removed

실험 절차

2-(6-Chloro-2-benzothienyl)-3-methylbutanoic acid (3.40 mmol) is stirred together with 0.34 g (3.40 mmol) KHCO3 in 10 ml THF/DMF (1:1) for 15 minutes. Then 3.40 mmol of 3-benzylpyrrolylmethyl methanesulfonate in 5 ml THF/DMF (1:1) is added and the mixture stirred for approximately 48 hours. The reaction is diluted with ether, washed with water (3×) and sat. NaCl, dried and solvent is removed to yield 3-benzylpyrrolylmethyl 2-(6-chloro-2-benzothienyl)-3-methylbutanoate.

출처