반응 #56221

반응 방정식

3-benzylpyrrolyl methanol

2-(5-fluoro-2-benzothienyl)-3-methylbutanoic acid

N,N'-dicyclohexylcarbodiimide

→

3-benzylpyrrolylmethyl 2-(5-fluoro-2-benzothienyl)-3-methylbutanoate

용매

methylene chloride

DMF

반응 조건

후처리

1. 1
   여과filtered
2. 2
   추출extracted with water
3. 3
   추출The aqueous phase is extracted with ether
4. 4
   세척The combined organic phases are washed with saturated aqueous NaHCO3, water and saturated aqueous NaCl
5. 5
   건조dried over CaSO4 and solvent
6. 6
   기타evaporated

실험 절차

To a stirred solution of 3-benzylpyrrolyl methanol (1.8 mmol), 2-(5-fluoro-2-benzothienyl)-3-methylbutanoic acid (2.0 mmol) and 4-dimethylaminopyridine (2.0 mmol) in 20 ml of methylene chloride and 2 ml of DMF is added N,N'-dicyclohexylcarbodiimide (2.0 mml). The reaction mixture is stirred, under nitrogen, for about two hours and then filtered and extracted with water. The aqueous phase is extracted with ether. The combined organic phases are washed with saturated aqueous NaHCO3, water and saturated aqueous NaCl, dried over CaSO4 and solvent evaporated to yield 3-benzylpyrrolylmethyl 2-(5-fluoro-2-benzothienyl)-3-methylbutanoate.

출처