반응 #56220

반응 방정식

3-benzylpyrrolylmethyl alcohol

triethylamine

2-(5-chloro-2-benzothienyl)-3-methylbutanoic acid

→

3-benzylpyrrolylmethyl 2-(5-chloro-2-benzothienyl)-3-methylbutanoate

용매

ether

반응 조건

후처리

1. 1
   기타quenched with saturated aqueous NaHCO3
2. 2
   세척The ether phase is washed with aqueous NaHCO3, water and brine
3. 3
   건조dried over sodium sulfate and solvent
4. 4
   기타evaporated

실험 절차

To a stirred solution of 3-benzylpyrrolylmethyl alcohol (0.99 mmol) and triethylamine (0.14 g, 1.38 mmol) in ether (about15 ml), under nitrogen, is added a solution of the acid chloride of 2-(5-chloro-2-benzothienyl)-3-methylbutanoic acid (1.5 mmol) in either. The mixture is stirred for about 60 minutes and then quenched with saturated aqueous NaHCO3. The ether phase is washed with aqueous NaHCO3, water and brine, dried over sodium sulfate and solvent evaporated to give 3-benzylpyrrolylmethyl 2-(5-chloro-2-benzothienyl)-3-methylbutanoate.

출처