반응 #56210

반응 방정식

α-cyano-4-fluoro-3-phenoxybenzyl alcohol

2-(2-benzothienyl)-3-methylbutanoic acid

N,N'-dicyclohexylcarbodiimide

→

α-cyano-4-fluoro-3-phenoxybenzyl 2-(2-benzothienyl)-3-methylbutanoate

용매

methylene chloride

dimethylformamide

반응 조건

후처리

1. 1
   여과filtered
2. 2
   추출extracted with water
3. 3
   추출The aqueous phase is extracted with ether
4. 4
   세척The combined organic phases are washed with saturated aqueous sodiun bicarbonate, water and saturated aqueous sodium chloride
5. 5
   건조dried over calcium sulfate and solvent
6. 6
   기타evaporated

실험 절차

To a stirred solution of α-cyano-4-fluoro-3-phenoxybenzyl alcohol (437 mg, 1.8 mmol), 2-(2-benzothienyl)-3-methylbutanoic acid (2.0 mmol) and 4-dimethylaminopyridine (0.65 mmol) in 20 ml of methylene chloride and 2 ml of dimethylformamide is added N,N'-dicyclohexylcarbodiimide (2.0 mmol). The reaction mixture is stirred, under nitrogen, for two hours and then filtered and extracted with water. The aqueous phase is extracted with ether. The combined organic phases are washed with saturated aqueous sodiun bicarbonate, water and saturated aqueous sodium chloride, dried over calcium sulfate and solvent evaporated to give α-cyano-4-fluoro-3-phenoxybenzyl 2-(2-benzothienyl)-3-methylbutanoate.

출처