반응 #56208

반응 방정식

methylene chloride

2-(5-chloro-2-benzothienyl)-3-methylbutanoic acid

K2CO3

α-cyano-3-phenoxybenzyl chloride

→

α-cyano-3-phenoxybenzyl 2-(5-chloro-2-benzothienyl)-3-methylbutanoate

용매

DMSO

ether

THF

반응 조건

후처리

1. 1
   기타reaction mixture
2. 2
   workup.STIRRINGstirred for about 48 hours
3. 3
   세척washed with water and brine
4. 4
   건조dried over Na2SO4 and solvent
5. 5
   기타removed

실험 절차

A mixture of 10 ml methylene chloride, 10 ml THF, 2-(5-chloro-2-benzothienyl)-3-methylbutanoic acid (0.5 g), K2CO3 (0.25 g) and α-cyano-3-phenoxybenzyl chloride (0.42 g) is stirred at RT for 15 hours. Then 5 ml of DMSO is added and reaction mixture stirred for about 48 hours. The mixture is taken up in ether, washed with water and brine, dried over Na2SO4 and solvent removed. The crude product is plated developing with 10% ethyl acetate/hexane to give α-cyano-3-phenoxybenzyl 2-(5-chloro-2-benzothienyl)-3-methylbutanoate.

출처