반응 #560965

반응 방정식

6-Bromoindazole

potassium hydroxide

methyl iodide

→

6-bromo-1-methylindazole

용매

methanol

diethyl ether

반응 조건

후처리

1. 1
   온도the mixture was refluxed for 2.5 h
2. 2
   온도The reaction was cooled
3. 3
   세척washed with water, brine
4. 4
   기타dried
5. 5
   농축concentrated
6. 6
   기타The product 6-bromo-1-methylindazole (160 mg) was separated from its isomer by Combiflash

실험 절차

6-Bromoindazole (400 mg) was dissolved in methanol (10 mL). To this solution, potassium hydroxide (450 mg) was added followed by methyl iodide (0.50 mL) and the mixture was refluxed for 2.5 h. The reaction was cooled, diluted with diethyl ether, washed with water, brine, dried and concentrated. The product 6-bromo-1-methylindazole (160 mg) was separated from its isomer by Combiflash.

출처