반응 #560964

반응 방정식

5-Bromo-2-methylphenyldiazonium tetrafluoroborate

potassium acetate

→

6-bromoindazole

수율 86.7%

용매

chloroform

반응 조건

후처리

1. 1
   여과The resulting mixture was filtered
2. 2
   세척washed with chloroform
3. 3
   농축The filtrate was concentrated
4. 4
   workup.DISSOLUTIONthe residue was dissolved in diethyl ether
5. 5
   세척which was then washed with water, brine
6. 6
   기타dried
7. 7
   기타the solvent was removed

실험 절차

5-Bromo-2-methylphenyldiazonium tetrafluoroborate (1.50 g) was added to a mixture of potassium acetate (1.0 g) and 18-crown-6 (70 mg) in chloroform (50 mL) at room temperature in portions and then the reaction was stirred for 2 h. The resulting mixture was filtered and washed with chloroform. The filtrate was concentrated, and the residue was dissolved in diethyl ether, which was then washed with water, brine, dried, and the solvent was removed to give the product 6-bromoindazole (0.9 g). The product was used in the next step without further purification.

출처