반응 #560841

반응 방정식

N-cyclohexyl-N-methylcyclohexanamine

3,4-dihydro-2H-pyran

N-(4-(3-bromopyridin-2-yloxy)phenyl)pyridin-2-amine hydrochloride

→

title compound

(±)-N-(4-(3-(3,4-DIHYDRO-2H-PYRAN-2-YL)PYRIDIN-2-YLOXY)PHENYL)PYRIDIN-2-AMINE

용매

Dioxane

반응 조건

후처리

1. 1
   기타before evacuating
2. 2
   workup.ADDITIONwas added
3. 3
   기타consumption of the starting material
4. 4
   온도the reaction mixture was cooled to room temperature
5. 5
   기타the volatiles were removed under reduced pressure

실험 절차

To a 25 mL microwave vial was added Bis(tri-tert-butylphosphine) palladium (0) (101 mg, 0.198 mmol) and N-(4-(3-bromopyridin-2-yloxy)phenyl)pyridin-2-amine hydrochloride (750 mg, 1.981 mmol) before evacuating and backfilling with nitrogen (2×). After addition of Dioxane (5.659 ml), N-cyclohexyl-N-methylcyclohexanamine (0.840 ml, 3.96 mmol), and 3,4-dihydro-2H-pyran (666 mg, 7.92 mmol) was added and the mixture was heated to 105° C. Following complete consumption of the starting material, the reaction mixture was cooled to room temperature and the volatiles were removed under reduced pressure. Following silica gel chromatography, the title compound was obtained as a racemic mixture. MS (ESI, pos. ion) m/z: 346.0. IC50 (uM) 0.064.

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