반응 #5608

반응 방정식

2-chloromethyl-5-benzyloxy-4-pyridone

tetrahydrofuran

dimethylamine hydrochloride

sodium hydroxide

→

5-benzyloxy-2-(N,N-dimethylamino)methyl-4-pyridone

수율 96.7%

용매

water

반응 조건

후처리

1. 1
   농축the mixture was concentrated under reduced pressure to dryness
2. 2
   workup.DISSOLUTIONThe residue was dissolved in methanol
3. 3
   여과the insoluble material was filtered off
4. 4
   기타The filtrate was evaporated in vacuo

실험 절차

To a mixture of 2-chloromethyl-5-benzyloxy-4-pyridone (1.0 g), tetrahydrofuran (10 ml) and water (10 ml) were added dimethylamine hydrochloride (1.31 g) and sodium hydroxide (0.64 g). After being stirred for 1.5 hours, the mixture was concentrated under reduced pressure to dryness. The residue was dissolved in methanol and the insoluble material was filtered off. The filtrate was evaporated in vacuo to give 5-benzyloxy-2-(N,N-dimethylamino)methyl-4-pyridone (1.0 g) as a powder.

출처