반응 #5605

반응 방정식

ethyl 1-pyrrolidineacetate

sodium hydride

2-(N,N-dimethylamino)ethanol

→

2-(N,N-dimethylamino)-ethyl 1-pyrrolidineacetate

반응 조건

후처리

1. 1
   기타The mixture was purged with nitrogen gas
2. 2
   온도heated gradually
3. 3
   기타while collecting the ethanol by-product in a Dean-Stark trap
4. 4
   기타The liquid reaction product
5. 5
   workup.DISTILLATIONwas distilled at 85° C. at a pressure of 100 μmHg

실험 절차

To a mixture of 80 g (0.51 mol) of ethyl 1-pyrrolidineacetate and 0.5 g of sodium hydride (in the form of a 60% by weight suspension in mineral oil) was added 48 g (0.54 mol) of 2-(N,N-dimethylamino)ethanol. The mixture was purged with nitrogen gas, heated gradually and then maintained at about 150° C. while collecting the ethanol by-product in a Dean-Stark trap. The liquid reaction product was distilled at 85° C. at a pressure of 100 μmHg to provide 2-(N,N-dimethylamino)-ethyl 1-pyrrolidineacetate. The structure of the product was confirmed by nuclear magnetic resonance and infrared spectral analysis.

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