반응 #5604
ord-e8381d73f4f9423dbff70d4f1bb4f249
반응 방정식
toluene
pyrrolidine
ethyl bromoacetate
→
ETHYL 1-PYRROLIDINEACETATE
반응 조건
상세 조건
See reaction.notes.procedure_details.
후처리
- 1온도maintaining the temperature below 30° C
- 2기타to precipitate pyrrolidinium bromide, which
- 3기타was separated by filtration
- 4기타The filtrate was evaporated under vacuum
- 5기타to provide a residue of about 241 g of ethyl 1-pyrrolinidineacetate
실험 절차
To an ice bath-cooled solution of 213.4 g (3 mol) of pyrrolidine in 450 mL of tetrahydrofuran was added dropwise over about 2 hours 250.5 g (1.5 mol) of ethyl bromoacetate, maintaining the temperature below 30° C. To this solution was added 150 mL of toluene to precipitate pyrrolidinium bromide, which was separated by filtration. The filtrate was evaporated under vacuum to provide a residue of about 241 g of ethyl 1-pyrrolinidineacetate.