반응 #56039

반응 방정식

5-cyano-6-formyl-2-piperidinyl-3-pyridine-carboxylic acid, ethyl ester

hydrazine hydrate

→

5-Cyano-6-methylidene-hydrazino-2-piperidinyl-3-pyridine-carboxylic acid, ethyl ester

용매

methanol

반응 조건

후처리

1. 1
   여과The title compound is filtered off
2. 2
   기타recrystallized from methanol

실험 절차

28.7 g of 5-cyano-6-formyl-2-piperidinyl-3-pyridine-carboxylic acid, ethyl ester (0.1 mol) are dissolved in 100 ml of methanol. 5.5 g of hydrazine hydrate are added and the solution is stirred at room temperature over night. The title compound is filtered off and recrystallized from methanol. Yield 20.5 g (68%); m.p. 168°-170° C.

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