반응 #56038

반응 방정식

5-cyano-6-methyl-2-piperidinyl-3-pyridine-carboxylic acid, ethyl ester

selenium dioxide

→

5-Cyano-6-formyl-2-piperidinyl-3-pyridine-carboxylic acid, ethyl ester

용매

ether

반응 조건

후처리

1. 1
   workup.DISTILLATIONThe solvent is distilled off in vacuo
2. 2
   기타the oily residue crystallized with diethyl ether

실험 절차

27 g of 5-cyano-6-methyl-2-piperidinyl-3-pyridine-carboxylic acid, ethyl ester (0.1 mol) and 12.2 g selenium dioxide (0.11 mol) are refluxed together in diethyleneglycoldimethyl ether with stirring for 1.5 hours. The solvent is distilled off in vacuo and the oily residue crystallized with diethyl ether. Yield 19 g (66%); m.p. 62°-64° C. (ether).

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