반응 #56033

반응 방정식

2-chloro-5-cyano-6-methyl-3-pyridine-carboxylic acid, ethyl ester

n-butylamine

→

2-Butylamino-5-cyano-6-methyl-3-pyridine-carboxylic acid, ethyl ester

용매

반응 조건

후처리

1. 1
   온도at reflux temperature
2. 2
   workup.ADDITIONAfter the addition
3. 3
   온도the mixture is refluxed for an additional hour
4. 4
   workup.ADDITIONpoured onto ice
5. 5
   기타2-butylamino-5-cyano-6-methyl-3-pyridine-carboxylic acid, ethyl ester precipitates

실험 절차

112 g of 2-chloro-5-cyano-6-methyl-3-pyridine-carboxylic acid, ethyl ester (0.5 mol) are dissolved in 300 ml of alcohol and 73 g of n-butylamine are dropped in at reflux temperature with stirring. After the addition is completed, the mixture is refluxed for an additional hour and then poured onto ice. 2-butylamino-5-cyano-6-methyl-3-pyridine-carboxylic acid, ethyl ester precipitates. Yield 116 g (89%); m.p. 61°-63° C. (petrol ether).

출처