반응 #56010

반응 방정식

malonic acid

diethanol amine

benzaldehyde

→

Bis-(hydroxyethyl)amino benzyl malonic acid

용매

methanol

반응 조건

후처리

1. 1
   기타equipped with a stirrer
2. 2
   온도reflux condenser
3. 3
   기타the reaction commenced
4. 4
   온도After refluxing the reaction mixture for 1 hour
5. 5
   기타the methanol was removed from the reaction mixture
6. 6
   온도heating to a temperature of about 50° C
7. 7
   기타then was triturated in acetone
8. 8
   기타the resulting acid isolated by filtration

실험 절차

Bis-(hydroxyethyl)amino benzyl malonic acid was prepared conventionally in a flask equipped with a stirrer and reflux condenser by first charging 0.1 mol of malonic acid, 0.1 mol of diethanol amine and 100 cc methanol. The contents were warmed to a temperature of about 20° C. and then 0.1 mol benzaldehyde were added to the flask and the reaction commenced. After refluxing the reaction mixture for 1 hour, the methanol was removed from the reaction mixture by coupling the flask to a vacuum source and heating to a temperature of about 50° C. The residue remaining in the flask then was triturated in acetone and the resulting acid isolated by filtration.

출처