반응 #56005

반응 방정식

1-butyl-4-(4-methoxyphenyl)-piperazine dihydrochloride

hydrobromic acid

→

4-(4-butyl-1-piperazinyl)phenol monohydrobromide

수율 81.0%

용매

acetic acid

반응 조건

후처리

1. 1
   온도refluxed overnight
2. 2
   기타The reaction mixture is evaporated
3. 3
   기타the residue is triturated in 2-propanone
4. 4
   여과The product is filtered off
5. 5
   기타crystallized from water

실험 절차

A mixture of 12.5 parts of 1-butyl-4-(4-methoxyphenyl)-piperazine dihydrochloride and 150 parts of hydrobromic acid solution 48% in glacial acetic acid is stirred and refluxed overnight. The reaction mixture is evaporated and the residue is triturated in 2-propanone. The product is filtered off and crystallized from water, yielding 13.1 parts (81%) of 4-(4-butyl-1-piperazinyl)phenol monohydrobromide; mp. 281.9° C.

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