반응 #55942

반응 방정식

water

methyl cyanoacetate

Methyl 2-amino-5-phenyl-thiophene-3-carboxylate

benzoyl chloride

→

N-(3-Carboxymethyl-5-phenyl-2-thienyl)-benzamide

용매

hexamethyl phosphoramide

반응 조건

후처리

1. 1
   workup.STIRRINGThe solution was stirred for 2 hours
2. 2
   여과the title compound filtered off (1.31 g) m.p. 190° C.

실험 절차

Methyl 2-amino-5-phenyl-thiophene-3-carboxylate (1.3 g, 0.0055 mole) in hexamethyl phosphoramide (prepared by the method of Chemische Berichte, 99, 94 (1966) but using methyl cyanoacetate in place of ethyl cyanoacetate) (20 ml.) was stirred and treated with benzoyl chloride (1.56 g, 1.28 ml, 0.011 mole). The solution was stirred for 2 hours, poured into water (750 ml), stored overnight and the title compound filtered off (1.31 g) m.p. 190° C.

출처