반응 #5594

반응 방정식

triethylamine

2,6-bis(1,1-dimethylethyl)-4-mercaptophenol

N-tricyclo[3.3.1.13,7 ]dec-2-yl-2-propenamide

→

3-[[3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl]thio]-N-tricyclo[3.3.1.13,7 ]dec-2-yl propanamide

용매

methanol

반응 조건

후처리

1. 1
   기타The solvent and triethylamine were removed on a rotary evaporator
2. 2
   기타the product purified by chromatography on silica
3. 3
   기타recrystallized from ethyl acetate/ethyl ether/hexane
4. 4
   기타dried

실험 절차

Following the procedure of Example 4, triethylamine (0.5 ml) was added to a solution of 2,6-bis(1,1-dimethylethyl)-4-mercaptophenol (1.19 g, 0.005 mole) and the N-tricyclo[3.3.1.13,7 ]dec-2-yl-2-propenamide (1.02 g, 0.005 mole) in methanol (100 ml) and the solution stirred at room temperature for 12 hours. The solvent and triethylamine were removed on a rotary evaporator and the product purified by chromatography on silica, recrystallized from ethyl acetate/ethyl ether/hexane and dried, m.p. ca. 155.5°-156° C.

출처